A major reason for this outcome is that a large proportion of lung cancer patients are diagnosed at advanced stages. Despite improvement in multimodal therapies, the 5-year survival rate for lung cancer is less than 10%. In China, lung cancer ranks first among the causes of cancer-related death. Worldwide, lung cancer is one of the most common cancers and the leading cause of cancer-related mortality among men, and the fourth leading cause of cancer morbidity and the second leading cause of cancer mortality among women. However, more epidemiological studies of larger samples and more ethnicities are needed to confirm these results. Despite some limitations, this meta-analysis indicates that the NQO1 C609T polymorphism may not be associated with lung cancer risk. A significant association was found in the subgroup of small cell lung cancer risk. In addition, no statistical significance was observed in the analysis stratified based on ethnicity, control source, quality score, or smoking status.
We found that the NQO1 C609T polymorphism did not correlate with the risk of lung cancer in the overall analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of relations. A total of 37 studies (29 articles) with 8493 cases and 10,999 controls were included. All relevant literature was retrieved from the PubMed, EMBASE, CNKI, and WanFang databases before April 2017. We conducted this updated meta-analysis to identify the function of NQO1 C609T polymorphism in lung cancer risk. Received: Accepted: AugPublished: September 19, 2017Ī variety of case-control studies have been performed to assess the correlation between NQO1 C609T polymorphism and the risk of lung cancer, but an explicit consensus has not been reached. Zhidong Zhang, email: NQO1, C609T, polymorphism, lung cancer, meta-analysis Jiawen Huang 1, Huiran Lin 2, Xiaosong Wu 1, Weijun Jin 1 and Zhidong Zhang 1ġDepartment of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong, ChinaĢAnimal Experimental Management Center, Public Technology Service Platform, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China
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